Colin Cowherd’s Blazin’ 5 Picks: NFL Week 12 in 2025

Colin couldn’t have scripted Week 11 any better, sweeping the board with a perfect 5–0 card. Everything lined up, every number hit, and now he heads into Week 12 riding his hottest stretch of the season.

Onto week 12…

Blazing 5 Record

2025 Season: 34-21 (61.8%)

Week 1: 3-2
Week 2: 2-3
Week 3: 1-4
Week 4: 3-2
Week 5: 3-2
Week 6: 4-1
Week 7: 4-1
Week 8: 4-1
Week 9: 2-3
Week 10: 3-2
Week 11: 5-0
Week 12:

Past Records

2024: 30-47-2 (39.0%)
2023: 45-35-5 (56.3%)
2022: 44-37-4 (54.3%)
2021: 39-47 (45.3%)
2020: 40-42-2 (48.8%)
2019: 42-41-3 (50.6%)
2018: 43-33-2 (57.7%)
2017: 43-29-3 (59.7%)
2016: 44-33-3 (57.1%)

Colin Cowherd Week 12 2025 Blazing 5

Packers −6.5 vs Vikings
Bears −2.5 vs Steelers
Colts/Chiefs over 50.5
Seahawks −13.5 at Titans
Panthers +7 at 49ers

Vikings at Packers (Packers −6.5)

Colin backed Green Bay because Jeff Hafley has quietly built one of the most fundamentally sound defenses in the league. They give up almost no explosive plays and consistently force turnovers. JJ McCarthy has multiple multi-pick games and struggles badly when he’s trailing. Colin expects the Packers defense to dictate the game and create short fields for Jordan Love. Packers win by forcing mistakes and controlling tempo.

Steelers at Bears (Bears −2.5)

Colin took Chicago, pointing to their seven wins in the last eight games and the emergence of a top-tier rushing attack. Caleb Williams is far more efficient at home, sack-free in three straight Chicago games. Pittsburgh’s defense collapses on the road, allowing 25 or more in three of four away games, and their offense can’t run the ball. Colin sees the Bears dominating possession and the scoreboard. Bears win and cover.

Colts at Chiefs (Over 50.5)

Colin attacked the total instead of a side. These are the two most efficient offenses in football and the two teams who punt the least. Shane Steichen off a bye means trick plays, scripted explosives, and tempo. Kansas City averages almost 30 at home, and both defenses are banged up. Colin expects long drives, big plays, and a back-and-forth game that pushes past the number. Chiefs win 28-24 but the over is the play.

Seahawks at Titans (Seahawks −13.5)

Colin normally avoids huge favorites but Tennessee is 0-5 at home and consistently loses by double digits. Seattle is one of the league’s best road teams because defense and the run game travel. Despite the interceptions last week, Sam Darnold remains one of the highest-graded QBs by PFF and the Seahawks outgained the Rams by 165 yards. Colin believes Tennessee is checked out and Seattle rolls. Seahawks dominate 31-13.

Panthers at 49ers (Panthers +7)

Colin grabbed the points because the 49ers defense is wrecked with injuries and producing the fewest sacks in the NFL. Bryce Young has quietly been efficient on the road with back-to-back 68 percent completion games. Carolina has won three straight road contests and often hangs around late. The Niners are erratic after wins and Colin doesn’t trust them to pull away. San Francisco wins but Carolina keeps it tight.