| Pick | Pitchers | Odds | Risk | To Win |
| San Francisco | Dinelson Lamet / Madison Bumgarner | -125 | 3.75 | 3 |
| Arizona | Tony Gonsolin / Zac Gallen | 115 | 2.61 | 3 |
| Chi. Cubs | Chase Anderson / Jose Quintana | -145 | 2.9 | 2 |
| Pittsburgh | Dario Agrazal / Antonio Senzatela | 125 | 1.6 | 2 |
| Oakland | Brett Anderson / CC Sabathia | 130 | 1.54 | 2 |
| Minnesota | Kyle Gibson / Edwin Jackson | -280 | 2.8 | 1 |
| Houston | Wade Miley / Trent Thornton | -200 | 2 | 1 |
| Cleveland | Shane Bieber / Austin Pruitt | -143 | 1.43 | 1 |
| Boston | Nathan Eovaldi / Jose Suarez | -125 | 1.25 | 1 |
| Baltimore | Dylan Bundy / Eric Skoglund | -112 | 1.12 | 1 |
| Seattle | Marco Gonzales / Kolby Allard | 105 | 0.95 | 1 |
| Cincinnati | Trevor Bauer / Dakota Hudson | 105 | 0.95 | 1 |
| NY Mets | Zack Wheeler / Aaron Nola | 135 | 0.74 | 1 |
| Chi. White Sox | Ivan Nova / Max Fried | 185 | 0.54 | 1 |
| Miami | Elieser Hernandez / Anibal Sanchez | 220 | 0.45 | 1 |
