| Pick | Pitchers | Odds | Risk | To Win |
| Chi. Cubs | Joe Ross / Jose Quintana | -160 | 4.8 | 3 |
| San Francisco | Madison Bumgarner / Chris Bassitt | 140 | 2.14 | 3 |
| San Diego | Nathan Eovaldi / Dinelson Lamet | 108 | 1.85 | 2 |
| Miami | Zach Eflin / Jordan Yamamoto | 110 | 1.82 | 2 |
| Arizona | Zac Gallen / Chase Anderson | 111 | 1.8 | 2 |
| Texas | Kolby Allard / Ivan Nova | 123 | 1.63 | 2 |
| Tampa Bay | Jose Alvarado / John Means | -175 | 1.75 | 1 |
| LA Dodgers | CC Sabathia / Tony Gonsolin | -137 | 1.37 | 1 |
| Pittsburgh | Alex Wood / Trevor Williams | 100 | 1 | 1 |
| Atlanta | Max Fried / Zack Wheeler | 100 | 1 | 1 |
| Toronto | Wilmer Font / Felix Hernandez | 114 | 0.88 | 1 |
| Colorado | Chi Chi Gonzalez / Dakota Hudson | 165 | 0.61 | 1 |
| LA Angels | Dillon Peters / Wade Miley | 190 | 0.53 | 1 |
| Detroit | Edwin Jackson / Kyle Gibson | 280 | 0.36 | 1 |
| Kansas City | Glenn Sparkman / Mike Clevinger | 300 | 0.33 | 1 |
