| Pick | Pitchers | Odds | Risk | To Win |
| Texas | Mike Minor / Asher Wojciechowski | -140 | 5.6 | 4 |
| Chi. Cubs | Jon Lester / Adrian Houser | 110 | 3.64 | 4 |
| NY Mets | Vince Velasquez / Noah Syndergaard | -160 | 4.8 | 3 |
| Cleveland | Mike Clevinger / Randy Dobnak | -160 | 3.2 | 2 |
| Miami | Mike Montgomery / Sandy Alcantara | 100 | 2 | 2 |
| Colorado | Peter Lambert / Eric Lauer | 140 | 1.43 | 2 |
| Houston | Felix Hernandez / Gerrit Cole | -450 | 4.5 | 1 |
| St. Louis | Jack Flaherty / James Marvel | -205 | 2.05 | 1 |
| Washington | Max Scherzer / Mike Soroka | -130 | 1.3 | 1 |
| NY Yankees | Masahiro Tanaka / Rick Porcello | -118 | 1.18 | 1 |
| Chi. White Sox | Jaime Barria / Dylan Cease | 110 | 0.91 | 1 |
| Arizona | Mike Leake / Anthony DeSclafani | 115 | 0.87 | 1 |
| Toronto | Jacob Waguespack / Tyler Glasnow | 180 | 0.56 | 1 |
| San Francisco | Dereck Rodriguez / Julio Urias | 210 | 0.48 | 1 |
| Detroit | Daniel Norris / Sean Manaea | 250 | 0.4 | 1 |
