| Pick | Pitchers | Odds | Risk | To Win |
| Minnesota | Martin Perez / Nathan Eovaldi | 130 | 3.08 | 4 |
| Detroit | Matthew Boyd / Glenn Sparkman | -115 | 3.45 | 3 |
| Chi. Cubs | Jose Quintana / Chase Anderson | -120 | 2.4 | 2 |
| Cincinnati | Jason Vargas / Sonny Gray | -162 | 1.62 | 1 |
| Washington | Stephen Strasburg / Max Fried | -110 | 1.1 | 1 |
| Texas | Kolby Allard / John Means | 105 | 0.95 | 1 |
| Miami | Elieser Hernandez / Dario Agrazal | 130 | 0.77 | 1 |
| San Francisco | Logan Webb / Dakota Hudson | 160 | 0.63 | 1 |
| LA Angels | Luke Bard / Brett Anderson | 165 | 0.61 | 1 |
| Toronto | Trent Thornton / Austin Pruitt | 175 | 0.57 | 1 |
| Chi. White Sox | Reynaldo Lopez / Zach Plesac | 180 | 0.56 | 1 |
| Seattle | Marco Gonzales / Wade Miley | 220 | 0.45 | 1 |
