| Pick | Pitchers | Odds | Risk | To Win |
| Atlanta | Wilmer Font / Mike Foltynewicz | -210 | 6.3 | 3 |
| NY Mets | Jacob deGrom / Max Scherzer | 125 | 2.4 | 3 |
| Arizona | Ronald Bolanos / Merrill Kelly | -125 | 2.5 | 2 |
| Detroit | Daniel Norris / Mike Montgomery | 128 | 1.56 | 2 |
| Cleveland | Dylan Cease / Mike Clevinger | -320 | 3.2 | 1 |
| St. Louis | Dereck Rodriguez / Jack Flaherty | -280 | 2.8 | 1 |
| Oakland | Jaime Barria / Mike Fiers | -170 | 1.7 | 1 |
| Houston | Zack Greinke / Jordan Lyles | -160 | 1.6 | 1 |
| Boston | Randy Dobnak / Rick Porcello | -145 | 1.45 | 1 |
| Philadelphia | Vince Velasquez / Lucas Sims | 110 | 0.91 | 1 |
| Miami | Sandy Alcantara / Mitch Keller | 155 | 0.65 | 1 |
| Seattle | Felix Hernandez / Jon Lester | 205 | 0.49 | 1 |
| Baltimore | Ty Blach / Trevor Richards | 207 | 0.48 | 1 |
| Colorado | Chi Chi Gonzalez / Julio Urias | 225 | 0.44 | 1 |
| Texas | Ariel Jurado / James Paxton | 280 | 0.36 | 1 |
