| Pick | Pitchers | Odds | Risk | To Win |
| LA Dodgers | Kenta Maeda / Trey Wingenter | -180 | 7.2 | 4 |
| Washington | Asher Wojciechowski / Max Scherzer | -450 | 9 | 2 |
| NY Mets | Kyle Hendricks / Noah Syndergaard | -126 | 2.52 | 2 |
| NY Yankees | James Paxton / Justus Sheffield | -220 | 2.2 | 1 |
| Cleveland | Aaron Civale / Jordan Zimmermann | -185 | 1.85 | 1 |
| Minnesota | Jake Odorizzi / Ross Detwiler | -185 | 1.85 | 1 |
| LA Angels | Emmanuel Clase / Patrick Sandoval | -180 | 1.8 | 1 |
| Boston | Eduardo Rodriguez / Peter Lambert | -170 | 1.7 | 1 |
| Oakland | Tanner Roark / Jakob Junis | -155 | 1.55 | 1 |
| Philadelphia | Mitch Keller / Vince Velasquez | -137 | 1.37 | 1 |
| Cincinnati | Anthony DeSclafani / Sandy Alcantara | -135 | 1.35 | 1 |
| St. Louis | Jack Flaherty / Jordan Lyles | -125 | 1.25 | 1 |
| Tampa Bay | Ryan Yarbrough / Gerrit Cole | 180 | 0.56 | 1 |
