Hate to keep picking on the Niners this week. We already suggested taking the Cardinals QB and Cardinals WR for this week. Unfortunately, for the Niners, Cardinals also have one of that top ranked defense in the league. There’s a reason why Arizona is a 10 point favorite on the road this week. It’s not going to be pretty. Have a feeling Cousin Sal and Bill Simmons are going to throw the Cardinals in a teaser this week.
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*Note: stats below are based on footballoutsiders.com’s DVOA analysis, be sure to check out their explanation on DVOA if you haven’t read about it before.
Best Defense to Start in 2015 NFL Week 12
| Name | DK Salary | GameInfo | Matchup DVOA |
| Cardinals | 3900 | Ari@SF 04:05PM ET | -31.3 |
| Bengals | 3000 | StL@Cin 01:00PM ET | -27.5 |
| Patriots | 3500 | NE@Den 08:30PM ET | -20.3 |
| Jets | 3200 | Mia@NYJ 01:00PM ET | -11.8 |
| Buccaneers | 2500 | TB@Ind 01:00PM ET | -8.5 |
| Ravens | 2800 | Bal@Cle 08:30PM ET | -5.9 |
| Falcons | 3100 | Min@Atl 01:00PM ET | -4.1 |
| Raiders | 2400 | Oak@Ten 01:00PM ET | -3.7 |
| Broncos | 2900 | NE@Den 08:30PM ET | -3.4 |
| Colts | 2000 | TB@Ind 01:00PM ET | -3.1 |