The only two undefeated teams in the league have one thing in common. Stingy defense. Vikings completely shut down the potent Giants offense in front of a national audience.
Best Defense to Start in 2016 NFL Week 5
| Name | Salary | GameInfo |
| Vikings | 3400 | Hou@Min 01:00PM ET |
| Bills | 3100 | Buf@LARM 04:25PM ET |
| Cardinals | 3700 | Ari@SF 08:25PM ET |
| Eagles | 2900 | Phi@Det 01:00PM ET |
| Panthers | 3300 | TB@Car 08:30PM ET |