The Kansas City Chiefs have listed tight end Travis Kelce as questionable for Thursday night’s regular season opener against the Detroit Lions. According to Adam Schefter, Kelce suffered a bone bruise to his knee during Tuesday’s practice, putting his availability in doubt.

According physical therapist Dr. Evan Jeffries, “The bone bruise is the biggest concern because of the amount of pain. This is common with hypertension knee injuries. This can linger for weeks and more than likely will be wearing a brace for protection.”

The Chiefs opened as 7-point favorites over the Lions, but the line has dropped to -4.5 with the uncertainty around Kelce, who is quarterback Patrick Mahomes‘ top target. Kelce’s potential absence would be a big blow to the Chiefs’ passing game.

If Kelce can’t play, backups Noah Gray and Blake Bell would see increased snaps. Wide receivers Kadarius Toney, Marquez Valdes-Scantling, and Skyy Moore could also be in line for more targets. For fantasy football, Gray, Bell, Moore and Toney might be viable waiver wire additions this week if Kelce sits.

The Chiefs have not definitively ruled Kelce out yet, but his status will need to be monitored leading up to kickoff on Thursday night. His availability could shift the spread and fantasy outlook for this matchup.