Jay Ajayi is going up against the 19th ranked defense in the league in San Diego, he’s been the hottest RB in the league. Ajayi is primed for a huge game.
Best Running Back to Start in 2016 NFL Week 10
| Name | Salary | GameInfo |
| Jay Ajayi | 7000 | Mia@SD 04:05PM ET |
| David Johnson | 8400 | SF@Ari 04:25PM ET |
| Le’Veon Bell | 7700 | Dal@Pit 04:25PM ET |
| Jacquizz Rodgers | 6200 | Chi@TB 01:00PM ET |
| Ezekiel Elliott | 7900 | Dal@Pit 04:25PM ET |