| Pick | Pitchers | Odds | Risk | To Win |
| Texas | Mike Minor / Andrew Heaney | 130 | 3.85 | 5 |
| Chi. White Sox | Michael Pineda / Lucas Giolito | 110 | 3.64 | 4 |
| Colorado | Rick Porcello / German Marquez | -109 | 3.27 | 3 |
| Washington | Aaron Brooks / Patrick Corbin | -305 | 6.1 | 2 |
| St. Louis | Miles Mikolas / Adrian Houser | 130 | 1.54 | 2 |
| NY Yankees | Masahiro Tanaka / Yusei Kikuchi | -180 | 1.8 | 1 |
| LA Dodgers | Walker Buehler / Cal Quantrill | -180 | 1.8 | 1 |
| Oakland | Mike Fiers / Mike Montgomery | -165 | 1.65 | 1 |
| Cincinnati | Luis Castillo / Caleb Smith | -145 | 1.45 | 1 |
| Cleveland | Adam Plutko / Spencer Turnbull | -140 | 1.4 | 1 |
| Chi. Cubs | Yu Darvish / Marcus Stroman | -102 | 1.02 | 1 |
| Pittsburgh | Steven Brault / Drew Smyly | 128 | 0.78 | 1 |
| Tampa Bay | Charlie Morton / Justin Verlander | 160 | 0.63 | 1 |
