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Colin Cowherd’s Blazin’ 5 Picks: NFL Week 11 in 2025

Colin stayed hot in Week 10, stacking another winning card and finishing 3–2. He’s not on a heater by accident either, the favorites-heavy approach keeps cashing, and he heads into Week 11 with momentum.

Onto week 11…

Blazing 5 Record

2025 Season: 34-21 (61.8%)

Past Records

  • 2024: 30-47-2 (39.0%)
  • 2023: 45-35-5 (56.3%)
  • 2022: 44-37-4 (54.3%)
  • 2021: 39-47 (45.3%)
  • 2020: 40-42-2 (48.8%)
  • 2019: 42-41-3 (50.6%)
  • 2018: 43-33-2 (57.7%)
  • 2017: 43-29-3 (59.7%)
  • 2016: 44-33-3 (57.1%)

Colin Cowherd Week 11 2025 Blazing 5

  • Bills -5.5 vs Buccaneers
  • Seahawks +3 at Rams
  • 49ers -2.5 at Cardinals
  • Browns +8.5 vs Ravens
  • Eagles -1.5 vs Lions

Bills -5.5 vs Buccaneers

Buffalo steps back into its element here — cold, windy weather at home against a battered warm-weather roster missing multiple weapons. The Bills have outgained opponents in three straight games and remain the league’s top rushing offense, which matters when the weather turns. Tampa, meanwhile, has dried up on offense, averaging just 18 points over the last three with virtually no healthy receivers. Add in the travel and the matchup plays directly into Buffalo’s physical style. Colin likes the Bills to win by a touchdown in a rugged game.

Seahawks +3 at Rams

Colin goes against the sharps here, grabbing Seattle plus the field goal in a matchup he views as a coin flip. The Seahawks have won 10 straight road games, protect the quarterback at an elite level, and generate pressure at a top-two rate — the Denver recipe he keeps referencing. Seattle extends drives behind 6.5 yards per play, and special teams is a real edge with a No. 1 PFF grade compared to the Rams’ erratic kicking situation. Colin sees this as a straight pick-em and loves getting points. Seattle wins outright.

49ers -2.5 at Cardinals

Brock Purdy is back, and Colin is immediately back on San Francisco after their worst loss of the season — a spot where well-coached teams typically rebound hard. Purdy has shredded Arizona historically, and the Cardinals limp in missing James Conner and Marvin Harrison Jr., stripping them of their best offensive identity. Arizona has dropped six of seven and fades badly in fourth quarters, while failing to generate any real pass rush. With the Niners getting healthier up front, Colin expects Purdy to have time and rhythm all day. San Francisco covers on the road.

Browns +8.5 vs Ravens

Colin loves Cleveland as a big home dog in a divisional spot they traditionally play tight. The Browns have not lost a home divisional game by more than one score since 2023, and Dylan Gabriel has stabilized their offense with clean play and better ball security. With Quinshon Judkins heating up, Cleveland can control tempo in cold weather while Baltimore faces its third straight road game — a spot that historically breeds fatigue and sluggish starts. Colin expects a scrappy, low-scoring game where the Ravens likely win but the number is simply too big. Browns cover.

Eagles -1.5 vs Lions

Philadelphia is a step-up team — 4-1 this year against opponents with winning records — and Colin loves them in this matchup of two of the NFL’s best rosters. The Eagles don’t turn the ball over (just four giveaways all season), finish drives in the red zone, and tend to play their sharpest football in marquee games. Detroit’s defense travels poorly, Jared Goff historically dips under 50°, and both Penei Sewell and Sam LaPorta are banged up. Colin trusts Philly’s physicality and cold-weather edge. Eagles win and cover at home.

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