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Colin Cowherd’s Blazin’ 5 Picks: NFL Week 13 in 2025

After weeks of running hot, Week 12 cooled Colin off with a tough 2–3 card. His two favorites (Packers and Bears) cashed easily, but the totals play, the big Seattle number, and the Panthers dog all went the wrong way.

Onto week 13…

Blazing 5 Record

2025 Season: 41-29 (58.6%)

Past Records

  • 2024: 30-47-2 (39.0%)
  • 2023: 45-35-5 (56.3%)
  • 2022: 44-37-4 (54.3%)
  • 2021: 39-47 (45.3%)
  • 2020: 40-42-2 (48.8%)
  • 2019: 42-41-3 (50.6%)
  • 2018: 43-33-2 (57.7%)
  • 2017: 43-29-3 (59.7%)
  • 2016: 44-33-3 (57.1%)

Colin Cowherd Week 13 2025 Blazing 5

  • Lions -2.5 vs Packers
  • Browns +6.5 vs 49ers
  • Dolphins -5.5 vs Saints
  • Buccaneers -2.5 vs Cardinals
  • Seahawks -9.5 vs Vikings

Lions -2.5 vs Packers

Colin opens the week by leaning into Thanksgiving home-team history, and Detroit fits the role perfectly. The Lions have won six of their last eight against the Packers, and with Dan Campbell calling plays again, this offense is averaging more yards per play than anyone else over the past three weeks. Detroit is simply a different machine when Campbell is steering the offense—more rhythm, more downhill physicality, and far more explosive efficiency.

Green Bay’s recent road résumé doesn’t exactly inspire confidence either. Their three road wins have come against Arizona, Pittsburgh, and the Giants, and since losing Tucker Kraft they’ve fallen off a cliff offensively—under 200 passing yards from Jordan Love and just 19 points per game. Two good teams, but Detroit has the matchup edge, the home-field edge, and the coaching edge. Colin sees the Lions winning and covering 28–24.

Browns +6.5 vs 49ers

This is the classic “wrong line for the situation” pick. Colin immediately jumped on Cleveland +6.5 because the Browns are at home with an elite defense and one of the deepest overall rosters in the league. And then there’s Myles Garrett—13 sacks in a month. No player in the league has 13 for the entire season, and Garrett just produced that in four weeks. Brock Purdy has been shaky lately, throwing multiple interceptions in four of his last five starts, and snowy, windy conditions only amplify his ball-security issues.

Colin also thinks the 49ers are overly reliant on Christian McCaffrey, who has been logging an insane workload, and the Browns match up well with teams that need their RB1 to stabilize the offense. Even if the 49ers win late, he sees a four-point game. Colin takes the points and calls it 24–20 San Francisco.

Dolphins -5.5 vs Saints

Colin absolutely loves Miami in this spot—one of his strongest convictions of the week. The Dolphins are coming off a bye, they’ve won three of their last four, and Mike McDaniel has them playing hard on both sides of the ball. Tua enters the game with back-to-back performances over 70 percent completion, and Miami’s run game has quietly looked sharper than it did in early October. Even the defense has shown signs of life, putting together two straight encouraging efforts.

New Orleans, meanwhile, is drifting. The Saints have been held under 20 points in six straight games and have become one of the league’s dullest, least-creative offenses. Colin loves the simple formula: an elite offensive coach at home, coming off a bye, facing a bottom-tier offense that struggles to score at all. Miami rolls 33–23.

Buccaneers -2.5 vs Cardinals

“The buck stops here.” Tampa finally gets its guys back: Bucky Irving returns, and Chris Godwin is set for full snaps. Colin doesn’t love the Bucs’ recent play, but he does love how they perform at home—averaging 27 points per game in Tampa. Their losses have also come against the Patriots, Bills, and Rams, all legitimate teams.

Arizona, on the other hand, has spiraled. The Cardinals are 1–8 since Week 3 and carry the league’s worst scoring defense over the last three weeks. Colin sees signs of quit in the building, and once a team’s body language goes bad in late November, it usually stays bad. Healthy weapons, soft opponent, home environment—all arrows point to Tampa. He takes the Bucs 27–20.

Seahawks -9.5 vs Vikings

Not Colin’s favorite number, but he still fires confidently here. Seattle has outgained ten straight opponents, a sign of a strong roster even when the scoreboard doesn’t line up cleanly. They played arguably their worst defensive half of the year last week… and still won. And they continue to protect Sam Darnold—fewest sacks allowed in the league—while producing one of the highest sack totals defensively.

Minnesota has the opposite issues: turnovers, inconsistency, and an undrafted rookie quarterback starting on the road in the Pacific Northwest. The Vikings have been held under 20 points in four of their last five games, and this is a nightmare matchup for their offensive line. Seattle, angry and at home, is a bad place for a battered offense. Colin calls it 32–13 Seahawks.

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