Colin Cowherd’s Blazin’ 5 Picks: NFL Week5 in 2025
Week 4 finally gave Colin Cowherd the kind of bounce-back weekend he’s been looking for. After a couple of rough breaks early in the season, the Blazin’ 5 settled in with a winning record, finishing 3–2. The card leaned heavily on favorites, and for the most part, those bets held up exactly the way he laid out on Friday’s show.
Minnesota stumbled and the Raiders couldn’t hold serve at home, but the Rams took care of business, the over in Patriots-Panthers was never in doubt, and Denver rolled to a statement win. It wasn’t a perfect week, but in betting, stacking winning records is the name of the game, and Colin got back on track with his first positive mark of the season.
Onto week 5…
Blazing 5 Record
2025 Season: 12-13 (48%)
Past Records
- 2024: 30-47-2 (39.0%)
- 2023: 45-35-5 (56.3%)
- 2022: 44-37-4 (54.3%)
- 2021: 39-47 (45.3%)
- 2020: 40-42-2 (48.8%)
- 2019: 42-41-3 (50.6%)
- 2018: 43-33-2 (57.7%)
- 2017: 43-29-3 (59.7%)
- 2016: 44-33-3 (57.1%)
Colin Cowherd Week 5 2025 Blazing 5
Raiders at Colts — Pick: Colts −7
Colin opens Week 5 with Indianapolis at home, laying the small number. He likes the Colts to win and cover, leaning on their league-best 6.5 yards per play and a balanced attack that scores on two-thirds of their drives. Daniel Jones has quietly completed over 71 percent of his throws in two home starts, and the protection has been solid. Las Vegas comes in beat up, without left tackle Colton Miller, and ranks near the bottom in giveaways and overall defense. Colin sees Indy’s line, run game, and efficiency creating separation by halftime. Prediction: Colts 28, Raiders 20.
Cowboys at Jets — Pick: Jets +3
This one’s about health and desperation. The Jets +3 are healthier, at home, and catching a Dallas team with 17 players on the injury list, including issues in the secondary and offensive line. When Justin Fields plays, the Jets average 27 points and nearly 400 yards, and Colin believes that dual-threat energy will stress a Cowboys defense that’s allowed 30+ points three straight games. With Dallas leaking big plays and missing pieces, Colin expects New York to pull an upset in a tight one. Prediction: Jets 28, Cowboys 27.
Broncos at Eagles — Pick: Broncos +3.5
Colin grabs the hook and backs Denver +3.5, citing Sean Payton’s October dominance and a team that’s lost twice only on last-second field goals. He calls Denver the league’s best combination of protecting and getting after the quarterback, while Philadelphia has been outgained in every game so far and sits near the bottom in sacks. Add in some A.J. Brown drama and offensive inconsistency, and this feels like the right time to buy the Broncos. Colin sees a close, low-scoring slugfest where the points matter. Prediction: Broncos 24, Eagles 23.
Buccaneers at Seahawks — Pick: Seahawks −3
Seattle checks every box: healthier, at home, disciplined, and explosive. Colin takes Seahawks −3 thanks to their second-best point differential in football and league-low penalty totals. Sam Darnold’s resurgence has been the perfect fit for Pete Carroll’s offense, while Baker Mayfield has racked up nine turnover-worthy throws per PFF, tied for the most in the league. Tampa’s defense is banged up, their offense lives on the edge, and Seattle rarely beats itself in this spot. Prediction: Seahawks 28, Buccaneers 23.
Titans at Cardinals — Pick: Over 41.5
For his prop-style pick of the week, Colin targets the Over 41.5. Neither Tennessee nor Arizona gets pressure on opposing quarterbacks, meaning Cam Ward and Kyler Murray will both have time to pick defenses apart. Arizona comes in off extra rest and tends to play looser at home, while Tennessee finally sees a soft secondary after four straight physical opponents. He expects sustained drives, deep completions, and a comfortable win for the Cards that pushes the total over easily. Prediction: Cardinals 31, Titans 13 (Over hits).